â¢Â Â Â 3-Â-year PhD studentship in mathematical modelling of the consequences of the decomposition of magnesium-Â-based bone implants in humans.
â¢Â Â Â Collaborate with a strong and enthusiastic multi-Â-disciplinary team towards the design of improved bone implant technologies.Â
Project Â Background Â and Â Aims: Â Advances Â in tissue Â engineering Â hasÂ enabled Â significant Â improvements Â to be made in the clinical treatment Â of damaged Â or malformed Â bone tissue. Novel magnesium Â based alloys offer exciting prospects for the next generation of bone implant technology, having many properties that make them better Â suited Â than Â currently Â used Â materials. Â However, the Â use Â of Â these Â new Â alloys Â requires Â much Â more understanding of how the alloys degrade in the body, how they spread and what are the likely consequences to health.Â Â The aim of this project is to augment laboratory experimentation Â on these alloys with mathematical modelling in order to accelerate their development and ultimately their clinical use for bone implantation.
Project Outline: The student undertaking Â this PhD studentship Â will be tasked with the development Â of new mathematical models, that incorporates biological knowledge and data, to reliably predict the decomposition, dispersal Â and potential Â pathological Â effects of prolonged Â magnesium Â releasedÂ from an implanted Â device. As part Â of Â a Â multi-Â-disciplinary Â team, Â the Â studentâs Â work Â will Â inform Â the Â tissue Â engineering Â collaborators Â on experimental direction and, in return, they will provide data for validation of the studentâs modelling work. The mathematical models will be analysed to help identify the most desirable properties of the magnesium alloy material in order to optimise bone healing and ensuring patient’s safety.Â Â
Project Â Supervisors:Â Dr Â John Â Ward Â (Department Â of Â Mathematical Â Sciences) Â and Â Dr Â Yang Â Liu Â (School Â of Mechanical and Manufacturing Engineering).Â Â
Applicant: Â candidates for this project Â will need Â at least Â an upper-Â-2nd Â undergraduate Â degree Â or masters Â in mathematics or a related subject and willing to engage in multi-Â-disciplinary research. Knowledge of differential equations, mathematical modelling and computational skills are advantageous. Due to funding conditions, only applicants with UK/EU fee status are eligible for the award.
Funding: Â The Â Graduate Â School Â studentship Â provides Â a Â tax-Â-free Â stipend Â of Â ï¿¡13726 Â per Â annum Â for Â a Â period Â of three years, plus coverage for tuition fees (full-Â-time UK/EU rate), research expenses and relevant travel costs.
For Further information on the project contact Dr John Ward (John.Ward@lboro.ac.uk). Â For information about the Department of Mathematics see Â http://www.lboro.ac.uk/departments/maths/postgraduate/research/ Â and informationÂ Â onÂ Â theÂ Â researchÂ Â inÂ Â tissueÂ Â engineeringÂ Â undertakenÂ Â atÂ Â theÂ Â universityÂ Â canÂ Â beÂ Â foundÂ Â at http://www.lboro.ac.uk/departments/mechman/research/groups/healthcareengineering/.
Start date: 1stÂ January 2013.
The deadline for applications is Monday December 9th 2013. Applications can be made online via the Apply link below. Â Candidates Â should Â use Â the Â referenceÂ Â GSS13Â Â on Â the Â application form for the âfundingâ section.