BBSRC MRes/PhD studentship The role of superoxide in DNA damage signalling

Reference Code: CB091


Name of the supervisor(s)
Dr J Rutherford, Institute for Cell and Molecular Biosciences (IcaMB)

This studentship is sponsored by BBSRC as part of the Doctoral Training Partnership (DTP).

Duration of the award
4 years (MRes Medical and Molecular Biosciences followed by a three-year PhD).

Project description
Our research focuses on the role of copper in eukaryotic biology.  An emerging area of interest is the role of the copper enzyme superoxide dismutase (Sod1) in eukaryotic signalling pathways. For example, in humans Sod1 is essential for the functioning of receptor tyrosinase kinases that have major roles in cancer and development. We use the yeast Saccharomyces cerevisiae as a model organism to study eukaryotic signalling as the available genetic and molecular tools allow the detailed characterisation of these pathways. Studies in yeast have also led to our understanding of the molecular basis of human copper diseases such as Menkes and Wilson’s disease. We have identified that copper metabolism in yeast is regulated in response to DNA damage. Our model is that copper is imported into cells to ensure the full activity of Sod1, which is required for the response of yeast to DNA damage. The aim of this project is to further our understanding of how copper, and in particular superoxide dismutase, impacts on the yeast DNA damage response and how the DNA damage pathway regulates copper metabolism. This will involve using a range of molecular, genetic and biochemical techniques that will give the student extensive experience and training as a molecular biologist. 

Also Read  PhD Studentship in Physics

Value of the award and Eligibility
Depending on how you meet the BBSRC’s eligibility criteria, you may be entitled to a full or a partial award. A full award covers tuition fees at the UK/EU rate and an annual stipend of £13,590 (2012/13). A partial award covers fees at the UK/EU rate only.

Person Specification
Candidates should have or expect to achieve a First Class or 2:1 Honours degree in a relevant science subject.

How to Apply
You must complete the University’s postgraduate application form. Select “Master of Research/Doctor of Philosophy (Medical Sciences) – Cell and Molecular Biosciences” as the programme of study. Only mandatory fields need to be completed (no personal statement required) but you must attach a copy of your CV and a covering letter, quoting the title of the studentship and reference number CB091.

Closing date for applications 
Prompt application is advised as this post is only available until a suitable candidate is appointed.

Further information
For further details please contact:
Dr J Rutherford
Telephone: +44 (0) 191 222 6282

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