Supervisors: Dr Scott L. Cockroft
This is a tax-free stipend covering tuition fees and living expenses at the standard EPSRC rate
(commencing at ~Â£13,726 per year from autumn 2013-early 2014 for a period of 3.5 years).
Interfacing Â biological Â and Â synthetic Â components Â provides Â opportunities Â for Â the Â creation Â of molecular devices with applications in nanotechnology. The Cockroft group is developing single- molecule methods for constructing membrane-bound DNA and protein-based supramolecular devices.1
This Â PhD Â project Â seeks Â to Â develop Â the Â first-ever Â synthetic Â transmembrane Â molecular machines and to study their operation at the single-molecule level. The interdisciplinary nature of this project will provide training in a broad range of methods spanning the fields of chemistry and biophysics:
â¢ DNA/organic synthesis of water-soluble molecular machines
â¢ single-molecule detection using patch-clamp electrophysiology
â¢ theoretical background in supramolecular chemistry and single-molecule biophysical techniques
Applicants should possess a steady hand and express a keen interest in DNA/organic synthesis, supramolecular chemistry and molecular machines. ApplicantsÂ should be inÂ possession ofÂ (orÂ expecting to obtain) a first class or upper-second class degree (or equivalent) in chemistry or otherÂ cognate discipline. To apply, email a copy of your CV to Â email@example.com,Â via the âApplyâ button below.
Please include a brief description of previous research experience, and the contact details of two referees.Â
The deadline for applications isÂ 5pm (UK time) on 31 July 2013. Â We cannot guarantee that late applications will be considered.
Further information: Informal enquiries should be directed to Â firstname.lastname@example.org
Tel: +44 (0)131 650 4758, http://homepages.ed.ac.uk/scockrof/research.php
1A. âA Single-Molecule Nanopore Device Detects DNA Polymerase Activity with Single-Nucleotide Resolutionâ S. L. Cockroft, J. Chu, M. Amorin, M. R. Ghadiri. J. Am. Chem. Soc. 130, 818â820 (2008) Featured in:
Nature: âS upramo lec ular Â Chem istry :Â Embrac e the Baseâ
Nature Nanotechnology: âNa nopo r es: D etecting Â DNAâ
1B. âBiological Nanopores for Single-molecule Biophysicsâ M. Long, S. L. Cockroft. ChemBioChem.
1, 25-34 (2010)
To apply click on the âApplyâ button below.
*** Please note the University of Edinburgh vacancy website may be down for periods of time on 27 June 2013 for maintenance.
This will not affect any un-submitted applications which have been partially completed and saved by applicants.Â
Once the site is back on-line candidates will be able to complete and submit applications.***