PhD Studentship in Analytical Chemistry Resistive pulse sensing for the detection of viruses



Applications are invited to work on an exciting collaborative project between Loughborough University Department of Chemistry, and Izon Science Limited.

Project overview

The research project aims to develop a new assay for the quantification of and detection of viruses. We hope to develop a strategy for the use of aptamer functionalised nano/ microparticles particles to bind to the virus creating a virus-particle conjugate. These conjugates will be characterised using Izon’s tunable resistive pulse sensing (TRPS) technology.

The applicant will be expected to develop new aptamer probes using our Closed Loop Aptameric Directed Evolution, (CLADE) technology. These will be immobilised onto the surface of superparamagnetic particles. The particles are to be then suspended in the sample and following the capture of the virus by the aptamer extracted using a magnet. The extraction, development and optimisation of the assay with the TRPS are key roles in the work. Izon’s TRPS method enables high-throughput individual particle resolution measurements as particles are driven through a size-tunable nanopore, one at a time. The technique adapts the principle of resistive pulse-sensing, which monitors current flow through an aperture, combined with the use of tunable nanopore technology, allowing the passage of ionic current and particles to be regulated by adjusting pore size.

Funding details

The position is for a fully funded 3 years studentship the funding comes from Loughborough University and Izon Science limited. The student would be positioned at Loughborough University for the majority of the award, but would be expected to travel to Oxford regularly to meet with Izon.  The studentships will cover tuition fees at the UK/EU rate. International (non EU) students may apply but due to funding restrictions will need to demonstrate that they can fund the difference in fees themselves.

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Applicants should have, or expect to obtain, an upper second or first class MChem degree, a Masters degree, or an equivalent qualification in chemistry, biochemistry, natural sciences or a closely related area.

For more information and informal inquiries please contact Dr M. Platt at [email protected], www.markplatt.yolasite.com/

Izon Science Limited – www.Izon.com

Izon Science designs and manufactures precision instrumentation for nano- and micro-scale particle analysis. The instrument systems, the qNano and qViro-X, are now in use in a wide range of research institutes and universities around the world.

Application

Please quote reference PlattAptVi in all correspondence, Submit a cover letter and CV with your application. The cover letter must contain a short paragraph covering your research interests and your motivation for the project.

Deadline for application 30/09/2013

Applications should be completed using the on-line application form by clicking the Apply link below

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