PhD Studentship Angiogenesis and its Control of Blood Vessel Physiology

Tumour & Vascular Biology Laboratories

Fully funded three-year MRC doctoral training PhD studentship (October 2013);

The above studentship is available supervised by Professor David Bates to work on the molecular mechanisms that control blood vessel physiology during vascular remodelling. Blood vessels use multiple signalling pathways including the delta-notch pathway to remodel during growth.

This project will involve in vivo physiological measurement of microvascular parameters such as vascular permeability, calcium signalling, and conducted vasodilatation, combining cell and molecular biological approaches to understanding the role of the delta-notch pathway in maintaining vessel integrity and function during angiogenesis. It will involve learning how to cannulate and perfuse capillaries in real time and image them by confocal microscopy, and high resolution fast scanning calcium imaging, preparing and using recombinant adenoviruses and measuring protein and RNA expression in vitro and in vivo. Further details are available at (

Students should have (or be expected to obtain) a first or upper second class BSc honours degree in a Life Sciences subject.

Due to funding restrictions, this studentship is only available to UK and/or EU nationals who fulfil residency criteria. 

The studentship pays fees at the H/EU rate and a maintenance stipend (£13,726 in 2013/14) which will rise in line with minimum Research Council rates.

To apply, please submit a covering letter and CV, with the name, address and full contact details including email contact of three referees to Donna Cannon, via the ‘Apply’ button below.

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Please quote ref. MED/1201.

Closing date: 14th July 2013.

Interviews will be held in late July.

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