Job Reference Number: UOS006716

Contract Type: Fixed-term for three years

Working Commitment: 100%

Faculty: Faculty of Medicine

Location: University School of Medicine and Biomedical Sciences INSIGNEO Institute for in silico medicine

Salary: Grade 7 £28,685 to £30,424 per annum (pro-rata)

Closing Date: 18 July 2013

The INSIGNEO Institute for in silico Medicine is an initiative between the Faculty of Engineering and the Faculty of Medicine at the University of Sheffield and the Sheffield Teaching Hospitals Foundation Trust. INSIGNEO intends to realise the scientific ambition behind the Virtual Physiological Human, producing a transformational impact on healthcare. While recently established, INSIGNEO is already considered one of worldwide-leading institutions in the area of in silico medicine research. For more information on INSIGNEO please see our web pages: http://www.insigneo.org/.

The Department of Human Metabolism combines strong basic and clinical science groups to create a major focus on translational research. This is well illustrated by the integration of the NIHR funded Biomedical Research Unit for Bone within the Department. The research strengths are in the fields of Musculoskeletal Research, Endocrinology, Diabetes and Reproductive Medicine, with cross-cutting themes in Clinical Pharmacology and Imaging. Research activity is supported through a broad portfolio of research funding. This includes project and programme grant support from major UK funding organizations such as the Medical Research Council, NIHR, the Arthritis Research Council, Diabetes UK and Leukaemia and Lymphoma Research. Substantial support from biotechnology and pharmaceutical companies has formed the basis for a significant knowledge transfer activity and the Department supports four University spinout companies (Asterion, Diurnal, Medella, Health Care Solutions). A major emphasis of the Department is in career development. This has been demonstrated by the success of members of the theme in attaining personal support through Fellowship schemes, which include NIHR, Arthritis Research Council Clinician Scientist and Clinical Research Fellowship awards.

This is an excellent research opportunity within the Department of Human Metabolism at the University of Sheffield to collaborate with the department of Mechanical Engineering as part of the INSIGNEO project. The project forms part of a project aimed at developing in silico simulations involved bone cell signalling and functions.

Applicants should hold a PhD in Cell/Bone Biology and be familiar with cell culture of both primary and cell line and have good understanding of molecular biology and cellular assays. The post is full time and available for two years. The post-holder will report to Prof Tim Skerry in the department of Human Metabolism at The University of Sheffield.

Experience of molecular biology including qPCR and end point PCR are essential and experience of array studies are desirable. Experience of protein detection assays are highly desirable including Western blotting, ELISA and flow cytometry.

Closing Date: 18/07/2013

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