PhD Studentship Validation of Novel PET Imaging Biomarkers

To celebrate the University’s research successes, the University of Hull is offering a PhD scholarship for candidates applying for the following project.

Closing Date: 14th August 2013

Start Date: 30 September 2013.  

Informal enquiries:

Dr.C. Cawthorne                +44 (0)1482 466776

Prof.J. Greenman              +44 (0)1482 465409

How to apply

Visit our website via the ‘Apply’ button below.

Project outline

An exciting opportunity is available starting 30 September 2013, for a fully funded full time PhD studentship to develop novel imaging biomarkers for cancer.

Estrogen receptor-a is expressed in most breast cancers, and patients with ERa-positive (ERa+) tumours have longer overall survival and better response to hormone based therapies. The Progesterone Receptor (PR) is an estrogen-regulated gene, and there is evidence that PR expression in response to ER stimulation is predictive of response to anti-estrogenic therapies. Although ER and PR status are measured immunohistochemically in current clinical practice, molecular imaging of this pathway offers the ability to assess the whole disease burden in a patient longitudinally, allowing the assessment of heterogeneity and changes in response to therapy that may inform clinical management. The aim of this project is to screen a library of putative PR binding PET imaging agents for use as imaging biomarkers, using a wide range of in vitro and in vivo techniques. The project will make use of the recently installed Bioscan PET/CT scanner at the University of Hull, part of the new PET Research Centre.

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Applicants should be highly motivated and have:

  • A minimum Upper Second Class honours degree in a relevant subject from a recognised Institution
  • Previous experience in the biological analysis of tissue will be an advantage

Further details

This full-time UK/EU PhD scholarship will include fees at the ‘home/EU’ student rate and maintenance of £13,726 (in 2013/14) for three years, depending on satisfactory progress.

PhD students at the University of Hull are required to follow modules for research and transferable skills development and gain a Masters level Certificate or Diploma in Research Training in addition to their research degree.

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