PhD Studentship Imaging Transport in Control Drug Release Materials Using Hyperpolarized 129Xe MRI.



Applications for a PhD studentship funded by the University of Nottingham are invited from UK or EU students. The studentship in physics/chemical engineering, at the medical interface, aims to develop magnetic resonance imaging (MRI) using hyperpolarized noble gases (xenon-129 and krypton-83) to characterise materials for controlled drug release. The studentship in this novel emerging area is at the physics, chemical engineering and medicine interface, requiring a broad range of interests, and the willingness to acquire a variety of new skills such as experimental laser setup, MRI protocols for transport studies, and theoretical and applied understanding of drug support porous materials. Specific attention in the project will be paid to the development of novel imaging methods characterising transport of fluids in porous media. The successful student will work closely with physicists and medical researchers in both physics and pre-clinical settings. Overall, the student should have a solid background in physical sciences although students with biomedical training are also strongly encouraged to apply.

Nottingham has a long and illustrious history in the field of MRI, and is widely regarded as one of the leading MRI centres in the world. Hyperpolarised MRI uses noble gases that are not poisonous or radioactive. The technique involves xenon or krypton gas being ‘pumped’ through laser irradiation before usage; the procedure enables MRI imaging of gas transport in drug release materials in real time. This information can then be used for controlled drug delivery.

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The student will acquire appropriate skills in a physics environment at the Sir Peter Mansfield Magnetic Resonance Centre and/or at the School of Engineering at the University of Nottingham, further training will be provided in the Queen Medical Centre, School of Medicine, University of Nottingham. The student will join a vibrant, multidisciplinary team focused on furthering hyperpolarized noble gas MRI and our understanding of drug delivery control. This is a unique opportunity for a student with strong engineering/ physics background to get an exposure to the forefront research in medical sciences. 

Funding Notes:

Students must have at least a 2.1 UK degree or equivalent in physical or chemical engineering sciences. Students with a biomedical background will be considered.  A Masters degree is desirable.

This studentship is available for a period of three years and covers fees at the UK/EU rate and a postgraduate stipend of £13,590 in year one with increments in line with Research Council Rates. Due to funding restrictions this studentship is only open to UK/EU students.

To submit an application please use the ‘Apply’ button below.

Please quote ref. MED/1229.

Closing Date: 12 February 2013

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