|Location||University of Melbourne, Department of Medicine|
|App. deadline||Applications accepted year round/until filled|
|Eligibility||Open to international applicants|
Title: MSBase at MelbourneBrain Centre Postgraduate Research Scholarship
Department:Medicine, Faculty of Medicine, Dentistry and Health Sciences, TheUniversity of Melbourne
Full-time PhD position commencing in2016
Primary supervisor: Dr Tomas Kalincik
Co-supervisor:Prof Helmut Butzkueven
Contact: [email protected]
Modelling disease outcomes in multiple sclerosis
Multiplesclerosis is the most common cause of neurological disability among youngadults, with the peak of onset in 3-4th decades of life. Almost half of thepatients with multiple sclerosis ultimately develop severe limitation ofactivities of daily living and independence, and less than half of thepatients maintain employment. Immunomodulatory and immunosuppressantdisease modifying therapies represent the standard of disease management inpatients with relapsing multiple sclerosis. However management ofprogressive multiple sclerosis, prediction of disease outcomes andindividually-tailored therapy still remain to be resolved.
Thispostgraduate research scholarship will utilise a global observationalcohort study and statistical modelling, including analysis of longitudinaldata, propensity score-based methods and individual predictive analysis, toaddress the questions of (i) treatment and outcomes of progressive multiplesclerosis, (ii) early predictive markers of treatment response, and (iii)the outcomes of various management decisions and treatment pathways.
Outcomes and impact
The researchcompleted in the course of the candidature will inform clinical practice ofmultiple sclerosis management globally. It will further our understandingof predictors of treatment response and will enable individualised multiplesclerosis therapy. The student will develop knowledge observationalclinical research, multivariable modelling, analysis of longitudinal data,neuroepidemiology and multiple sclerosis – disease and treatmentoutcomes.
MSBase is a large, international,observational multiple sclerosis registry, collecting longitudinal clinicalinformation from over 37,000 patients in 119 centres and 35 countries. Itis a collaborative research initiative with a significant scientific outputgenerated over the past five years.
The Melbourne Brain Centre atRoyal Melbourne Hospital is an internationally recognised centre forclinical multiple sclerosis research, including investigator-drivenmultiple sclerosis