Research Associate – Developing a cellular model of Motor Neuron Disease



(Fixed Term)

Applications are invited for a Post-Doctoral Research Associate in the Centre for Misfolding Diseases who will investigate the translocation and trafficking of TDP-43, a protein related to Motor Neuron Disease, within a mammalian cell model system. The project involves using fluorescence microscopy techniques to monitor the real-time translocation of TDP-43 from the nucleus to the cytoplasm with the aim of understanding the molecular mechanisms of this process and how they may relate to the manifestation of disease.

The successful candidate will use real-time imaging techniques and they will also perform co-localisation studies to understand the trafficking of the protein of interest, as well as use biochemical analysis (western blotting, ELISAs, staining/imaging) of sample lysates. To complement the cellular work, the project may also involve looking at TDP-43 aggregation using in vitro biophysical techniques.

Applicants will have a Ph.D. in relevant discipline. Extensive experience with tissue culturing techniques is essential and experience creating transfected cell lines is desirable. They will have experience with confocal microscopy imaging, in particular with IHC staining techniques and also with real-time imaging. The candidate will have excellent communication skills and the ability to work effectively as part of a multi-disciplinary team.

Fixed-term: The funds for this post are available for 1 years in the first instance.

To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/11131. This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the ‘Apply online’ button and register an account with the University’s Web Recruitment System (if you have not already) and log in before completing the online application form.

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Please ensure that you upload your Curriculum Vitae (CV), a covering letter and publications list in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

For queries regarding applying online for this post, please contact Miss. Karen Valelli ([email protected]).

For more information about the post please contact Dr. Janet Kumita (

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