Supervisor: Professor Tim Skerry and Dr Gareth Richards
Many cancers kill because of metastatic spread from the primary tumour to other sites such as the liver and lungs.Â Increasing evidence suggests that cells which have left the primary tumour utilise the hormone adrenomedullin to signal to host cells in the new site in order to establish favourable conditions for growth. This project is to examine this phenomenon in more detail using samples from human clinical cases, and to determine the effect of blockade of AM-2 receptors on tumour cell proliferation, growth and spread.Â
The project will form part of a wider drive to develop ways to inhibit adrenomedullin signalling as a therapy for cancer patients, using novel antagonists.
Candidates must have a first or upper second class honors degree or significant research experience.
Interested candidates should in the first instance contact Professor Tim Skerry ([email protected]).
How to apply:
Please complete a University Postgraduate Research Application form and attach at least two references to your application. To complete the application form please click on theÂ ‘Apply’ button below.
Please clearly state the prospective main supervisor in the respective box and select âHuman Metabolismâ as the department.
Closing date: 3rd February 2014