PhD Studentship Metal–Free Aliphatic and Aromatic C-H Functionalization

Supervisor: Professor David Procter

Anticipated start date for project: 16 September 2013

Closing date for applications: 31 July 2013

The PhD project will involve the development of metal-free processes for the formation of C-C bonds to aromatic/heteroaromatic rings with substitution of an sp2 C-H bond and either an sp2 or sp3 C-H bond in the other coupling partner. The approach utilizes readily-installed organosulfinyl motifs (S(O)R) as directing groups for metal-free C-H functionalization. Crucially, the new processes will exploit delivery of the nucleophilic partner to the sulfur of the aryl/heteroaryl partner followed by intramolecular delivery to its aromatic ring. Thus, our strategy will use an easy bond-formation (C-S) to facilitate a challenging bond-formation (C-C). For the introduction of this metal-free cross-coupling strategy by our team, see: Eberhart, A. J.; Imbriglio, J. E.; Procter, D. J. Org. Lett. 2011, 13, 5882. Eberhart, A. J.; Procter, D. J. Angew. Chem. Int. Ed. 2013, 52, 4008

Qualifications applicants should have/expected to receive:

Applicants should have or expect a good (I or II(i)) honours degree (or an equivalent degree) in Chemistry.

The studentship will cover tuition fees at the UK/EU rate and a stipend of £13,726 per year for 3.5 years.

For further details please contact Professor David Procter by email, including a CV. david.j.procter@manchester.ac.uk;

Tel: 0161 275 1425

You can also submit a formal application. Please see application details via the ‘Apply’ button below.