|Location||University of Queensland, Queensland Brain Institute|
|Eligibility||Open to international applicants|
PhD Studentship in Neuroscience (lipidomics)
Area: Queensland Brain Institute
Salary (FTE):APAScholarship NON-BANDED ($26,288.00 – $26,288.00)
Work type:Full Time -Scholarship
Location: St Lucia
Established in 2003, QBI(http://www.qbi.uq.edu.au) is housed on the St Lucia campus of UQ. It ishome to more than 400 staff, including 36 group leaders, working across arange of disciplines, who are focussed on discovering the fundamentalmechanisms that regulate brain development and function in health anddisease.
Over the past decade QBI has become one of the world’sleading neuroscience research institutes. It played a key role incontributing to UQ attaining the highest possible score of 5 forneuroscience, in the 2010, 2012 and 2015 Excellence in Research forAustralia (ERA) reviews, one of only two universities in Australia toachieve this.
How lipids control theway our brain cells communicate and acquire or lose memories duringdegeneration has remained surprisingly unclear. Our ARC and NHMRC fundedlaboratory is using new state-of the-art lipidomics techniques andsuper-resolution microscopy, in combination with biochemistry to understandthe molecular mechanisms underpinning brain cell communication [1-9]. In arecent study, we developed a novel holistic and unbiased multiplex methodallowing the determination of all common free fatty acids with nanomolarsensitivity .
The aim of this PhD studentship is to pursue oureffort to characterise the change in the lipid landscape elicited bysynaptic transmission, memory acquisition paradigms andneurodegeneration.
The successful candidate will join the establishedlaboratory group of Professor Frederic Meunier at the Queensland BrainInstitute at the University of Queensland and will use new generationstate-of-the-art mass spectrometry or super-resolution microscopyapproaches to further understand how lipids control brain function anddysfunction. To know more about the lab group and its leader, ProfessorFred Meunier, please go to the following link:http://www.qbi.uq.edu.au/group-leader-meunier
1. Martin, S., et al.,Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads toapoptosis-independent neuronal cell death. PLoS One, 2013. 8(3): p.e60152.
2. Martin, S., et al., Increased polyubiquitination andproteasomal degradation of a Munc18-1 disease-linked mutant causestemperature-sensitive defect in exocytosis. Cell