A high number of new drug candidates, often complex in molecular structure, exhibit very poor solubility posing a major problem in product development and difficulty in formulation. One potential option is to generate particles in the nanometer size range, as the particles may dissolve faster increasing bioavailability. Several methods have been investigated and successfully demonstrated for the generation of nanoparticles, these include micronisation, milling, bead milling and spray drying. The effect of the size reduction processes is not merely a reduction in particle size, but may have an impact on powder physicochemical properties and their performance â the focus of this proposed PhD studentship, in collaboration with Pfizer Ltd., UK.
Students with a First or high Upper Second Class Degree (in Physics / Chemistry / Chemical Engineering / Materials Science/) are invited to apply. Experience with proteins/enzymes, crystallisation and/or surface chemistry will be advantageous. The stipend is of the order of Â£15,000/pa. In addition, home fees will be covered (i.e. the fees applicable for most UK and EU students) and an annual CASE supplement of ~Â£2k. To be eligible for support, applicants must be âUK Residents’ as defined by the EPSRC; this includes EU citizens who have been resident in the UK for a period of 3 years for any purpose, including undergraduate studies.
This project is funded by an EPSRC Industrial Case studentship with Pfizer Ltd., UK. The student will be expected to spend a minimum of 3 months placement at Pfizerâs research facilities in Sandwich, Kent.
Enquiries and applications (c.v. and contact details of 2 referees) should be sent to: Dr J. Heng, Department of Chemical Engineering, Imperial College London, South Kensington, SW7 2AZ, UK. Email [email protected]Â
Closing Date: 31 August 2013
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