MSc by Research Studentship (1 year) The Expression & Roles of Ationic Host Defence Peptides in Crohn’s Disease



Area of Research: Cell Biology, Host Defence, Inflammation

Anticipated Start Date: 1st June 2014

?Funding

This is a fees-only Studentship (fees are paid by the School of Life, Sport and Social Sciences) over 12 months.?Laboratory and reagent costs are paid by the University.?

Project Description

This project is based in the Biomedicine Research Theme within the School of Life, Sport and Social Sciences and is part of a collaboration with investigators at the University of Edinburgh Institute of Genetics and Molecular Medicine.?The project is led by Dr. Peter Barlow and Dr. Craig Stevens, and is focused upon the expression of Cationic Host Defence Peptides (CHDP; also known as antimicrobial peptides) and modulation of cell death pathways in Crohn?s Disease.?

CHDP are key components of the innate immune response against infection.?They are upregulated at sites of infection and inflammation and possess powerful immunomodulatory potential.

Crohn?s Disease is an incurable inflammatory disease of the bowel and is characterised by severe abdominal pain, inflammation and dysregulated cell death.?There is an intimate link between bacterial infection, programmed cell death, or apoptosis, and the pathogenesis of Crohn?s Disease.?This project will allow us to characterise the multiple roles of CHDP in Crohn?s Disease and will inform the development of novel therapeutics.?

Person specification

Applicants should have or expect to gain a good honours degree in a related subject.?

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Contacts

Dr Peter Barlow [email protected] or Dr Craig Stevens [email protected] for further information.?

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