M.Res Studentship in Biological Chemistry



Qualification, Duration, Mode: MSc (Masters by Research), 12 Months duration, Full-Time,

Project Start Date – 1st July 2016

Funding

Fees-only studentship (fees / all laboratory & reagent costs are paid by the School of Life, Sport and Social Sciences) over 12 months.

PROJECT 1 – Reference PG1SE

Area of Research

Computational Biological Chemistry, Drug Design, Nonsteroidal Anti-Inflammatory Drugs

Project Description

This project is based in the computational biological chemistry research group of Dr Stefan Erhardt. The interactions of small molecules with enzymes will be investigated. Inhibition mechanisms of known drugs are studied to gain deeper insight into their mode of action and to develop novel more potent inhibitors with potentially less side effects.

The long-term usage of ibuprofen or other nonsteroidal anti-inflammatory drugs (NSAIDs) can lead to gastric adverse effects. On the other hand some drugs which were prescribed in the past could lead to a higher heart attack risk. Particularly patients who suffer from arthritis would benefit from the development of novel anti-inflammatory drugs. However, recent studies have also indicated the importance of NSAIDs in the prevention and treatment of cancer. The results of computational study will be used to synthesise novel compounds and then test their biological activity.

Computational modelling techniques such as molecular docking, density functional theory, molecular dynamic and QM/MM calculations will be employed. No prior knowledge of computational biology is required. A strong biochemical background would be beneficial.

Also Read  Funded MRes Scholarship: Validation of a Hollow Fibre Infection model for in vitro dynamic evaluation of antimicrobial efficacy against veterinary pathogens

Contact Dr Stefan Erhardt ([email protected]) for more information.

The closing date for this studentship is Tuesday 31st May 2016.

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