Reference Code: IA060

Name of the supervisor(s)
Professor T von Zglinicki, Newcastle University
Dr JPassos, Newcastle University
Professor J Kirkland, Mayo Clinic Rochester, MN

Sponsor
This studentship is sponsored by BBSRC as part of the Doctoral Training Partnership (DTP)

Duration of the award
4-year MRes/PhD

Project description
Cell senescence may be a relevant driver of mammalian ageing. For instance, ablation of senescent cells ‘cured’ some age-related functional disabilities in mice (Baker et al. Nature 2011). Until very recently, senescence has only been thought of in the context of replication-competent cells, i.e. as a potential ageing mechanism in proliferating tissues. We showed for the first time that postmitotic neurons in the brain and other tissues also develop a senescent (Jurk et al Aging Cell 2012). This is important as it opens up a new inroad into understanding and potentially modifying ageing in postmitotic tissues.

The student will test the hypothesis that multiple postmitotic cells (myocytes, cardiomyocytes, adipocytes) develop a senescent phenotype and that this might contribute to ageing in the respective tissues. He/she will work to about equal parts at the Institute for Ageing and Health, Newcastle University and at the Robert and Arlene Kogod Center on Ageing, Mayo Clinic, ensuring the use of the most informative mouse models, the best available methodology and intense knowledge transfer between both labs.

Value of the Award and Eligibility
4-year studentship including stipend, University fees and travel allowance. Depending on how you meet the BBSRC’s eligibility criteria, you may be entitled to a full or a partial award. A full award covers tuition fees at the UK/EU rate and an annual stipend of £13,590 (2012/13). A partial award covers fees at the UK/EU rate only.

Person Specification
Candidates must have a BSc in an appropriate scientific specialty at either First or 2:1 level.

How to Apply
You must complete the University’s online postgraduate application form. Select ‘Master of Research/Doctor of Philosophy (Medical Sciences) – ageing and health’ as the programme of study. Only mandatory fields need to be completed (no personal statement required) but you must attach a copy of your CV and a covering letter, quoting the title of the studentship and reference number IA060.

Closing date for applications 
Prompt application is advised as this post is only available until a suitable candidate is appointed.

Further Information
For further details, please contact
Professor Thomas von Zglinicki
E-mail: t.vonzglinicki@ncl.ac.uk